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Chapter 24 - Endogenous estradiol and dementia in elderly men: the roles of vascular risk, sex hormone binding globulin, and aromatase activity

from Section 5 - Testosterone, estradiol and men, and sex hormone binding globulin

Published online by Cambridge University Press:  06 July 2010

Eef Hogervorst
Affiliation:
Loughborough University
Victor W. Henderson
Affiliation:
Stanford University, California
Robert B. Gibbs
Affiliation:
University of Pittsburgh
Roberta Diaz Brinton
Affiliation:
University of Southern California
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Summary

Editors' introduction

In elderly men as in elderly women, endogenous estradiol may play an important role in age-related cognitive impairment. To explore the relation between estradiol, cognition, dementia, and cerebral atrophy, Muller and Geerlings performed a systematic literature review. In their review, the authors found that most studies in elderly men do not report significant associations between estradiol levels and cognitive performance, cognitive decline, dementia, or brain atrophy. Some studies, however, do imply that higher estradiol levels are potentially detrimental, although to the extent that a relation may exist, the magnitude of risk is likely small. Given the long preclinical phase of Alzheimer's disease (AD), it is difficult to infer causality, even in longitudinal studies with long follow-up. Muller and Geerling indicated that the relation between estradiol and vascular risk merits further study with respect to AD. In addition, they provide evidence that sex hormone binding globulin (SHBG) levels and aromatase activity are relevant to questions of AD pathogenesis.

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Chapter
Information
Hormones, Cognition and Dementia
State of the Art and Emergent Therapeutic Strategies
, pp. 228 - 241
Publisher: Cambridge University Press
Print publication year: 2009

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