Book contents
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Chapter 11 Progesterone regulation of neuroprotective estrogen actions
- Chapter 12 Clinical data of estrogen's effects in the central nervous system: estrogen and mood
- Chapter 13 Different forms of soy processing may determine the positive or negative impact on cognitive function of Indonesian elderly
- Chapter 14 Hypothalamus-pituitary-adrenal axis activity in aging women: its impact on the brain and the potential influence of estradiol
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Section 6 Gonadotropin effects
- Index
- Plate Section
Chapter 12 - Clinical data of estrogen's effects in the central nervous system: estrogen and mood
from Section 3 - Potential modulators and modifiers of estrogenic effects
Published online by Cambridge University Press: 06 July 2010
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Chapter 11 Progesterone regulation of neuroprotective estrogen actions
- Chapter 12 Clinical data of estrogen's effects in the central nervous system: estrogen and mood
- Chapter 13 Different forms of soy processing may determine the positive or negative impact on cognitive function of Indonesian elderly
- Chapter 14 Hypothalamus-pituitary-adrenal axis activity in aging women: its impact on the brain and the potential influence of estradiol
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Section 6 Gonadotropin effects
- Index
- Plate Section
Summary
In this chapter, Rasgon and colleagues first review the neurochemical basis underlying estrogen therapy use in mood disorders. They follow with an analysis of changes in estrogen and mood during different hormonal states associated with the menstrual cycle, birthing, and menopause. Results of their analysis indicate that a considerable body of basic science findings support the assertion that estrogens are prime regulators of the neurobiology of mood in women. However, there is discordance between results of animal and human studies. The source of disparity between the basic and clinical science outcomes remains undetermined but indicates the need for larger clinical trials and longitudinal studies that could identify women who are likely to respond well to estrogen monotherapy and estrogen augmentation to antidepressant treatments.
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- Information
- Hormones, Cognition and DementiaState of the Art and Emergent Therapeutic Strategies, pp. 110 - 120Publisher: Cambridge University PressPrint publication year: 2009