When researchers account (literally) for physical processes such as the management of matter, energy, masses and of space and place, they follow certain housekeeping principles. To do so, they have developed numerous instruments and techniques of intervention as well as various ways of representing the results. All these activities are essentially economic activities: weighing, recording, measuring, metering, comparing, calculating, consolidating and, finally, accounting for what all these activities have provided in terms of theoretical knowledge and experimental practices. What makes this a political, rather than a moral or cognitive economy, is the fact that a decision is to be made about how the housekeeping is to be managed and what is to be its benefit (theories or products, discovery or innovation, fundamental or applied knowledge, etc.). Essentially there are two modes of housekeeping: one is an economy that follows a logic of adaption to limits while the other is an economy that strives for conquest and thus seeks to transgress limits. Given the foregoing discussion on the practices of experiments, it is apparent that these are decisions of eminent political relevance.