Skip to main content Accessibility help
Hostname: page-component-55597f9d44-vkn6t Total loading time: 0.847 Render date: 2022-08-14T13:38:05.143Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true } hasContentIssue true

Chapter 10 - Anesthesia for Fetal Neurosurgery

Published online by Cambridge University Press:  02 November 2018

Sulpicio G. Soriano
Boston Children’s Hospital
Craig D. McClain
Boston Children’s Hospital
Get access


Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Publisher: Cambridge University Press
Print publication year: 2018

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)


Brusseau, R, Mizrahi-Arnaud, A. Fetal anesthesia and pain management for intrauterine therapy. Clin Perinatol. 2013;40(3):429–42.CrossRefGoogle ScholarPubMed
Harrison, MR. Fetal surgery. Am J Obstet Gynecol. 1996;174(4):1255–64.CrossRefGoogle ScholarPubMed
Manning, FA, Harrison, MR, Rodeck, C. Catheter shunts for fetal hydronephrosis and hydrocephalus. Report of the International Fetal Surgery Registry. N Engl J Med. 1986;315(5):336–40.CrossRefGoogle ScholarPubMed
Bruner, JP, Davis, G, Tulipan, N. Intrauterine shunt for obstructive hydrocephalus—still not ready. Fetal Diagn Ther. 2006;21(6):532–9.CrossRefGoogle Scholar
Ferschl, M, Ball, R, Lee, H, Rollins, MD. Anesthesia for in utero repair of myelomeningocele. Anesthesiology. 2013;118(5):1211–23.CrossRefGoogle ScholarPubMed
Meuli, M, Meuli-Simmen, C, Yingling, CD, Hutchins, GM, Timmel, GB, Harrison, MR, et al. In utero repair of experimental myelomeningocele saves neurological function at birth. J Pediatr Surg. 1996;31(3):397402.CrossRefGoogle ScholarPubMed
Adzick, NS, Thom, EA, Spong, CY, Brock, JW III, Burrows PK, Johnson MP, et al. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med. 2011;364(11):9931004.CrossRefGoogle Scholar
Danzer, E, Thomas, NH, Thomas, A, Friedman, KB, Gerdes, M, Koh, J, et al. Long-term neurological outcome, executive functioning, and behavioral adaptive skills following fetal myelomeningocele surgery. Am J Obstet Gynecol. 2013;208(suppl 1):S183.CrossRefGoogle Scholar
Rychik, J, Tian, Z, Cohen, MS, Ewing, SG, Cohen, D, Howell, LJ, et al. Acute cardiovascular effects of fetal surgery in the human. Circulation. 2004;110(12):1549–56.CrossRefGoogle ScholarPubMed
Rychik, J, Cohen, D, Tran, KM, Szwast, A, Natarajan, SS, Johnson, MP, et al. The role of echocardiography in the intraoperative management of the fetus undergoing myelomeningocele repair. Fetal Diagn Ther. 2015;37(3):172–8.CrossRefGoogle ScholarPubMed
Ngamprasertwong, P, Michelfelder, EC, Arbabi, S, Choi, YS, Statile, C, Ding, L, et al. Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcomes in a sheep model. Anesthesiology. 2013;118(4):796808.CrossRefGoogle Scholar
Boat, A, Mahmoud, M, Michelfelder, EC, Lin, E, Ngamprasertwong, P, Schnell, B, et al. Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgery. Paediatr Anaesth. 2010;20(8):748–56.CrossRefGoogle ScholarPubMed
Lin, EE, Tran, KM. Anesthesia for fetal surgery. Semin Pediatr Surg. 2013;22(1):50–5.CrossRefGoogle ScholarPubMed
DiFederico, EM, Burlingame, JM, Kilpatrick, SJ, Harrison, M, Matthay, MA. Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery. Am J Obstet Gynecol. 1998;179(4):925–33.CrossRefGoogle ScholarPubMed
Fisk, NM, Gitau, R, Teixeira, JM, Giannakoulopoulos, X, Cameron, AD, Glover, VA. Effect of direct fetal opioid analgesia on fetal hormonal and hemodynamic stress response to intrauterine needling. Anesthesiology. 2001;95(4):828–35.CrossRefGoogle ScholarPubMed
Lee, SJ, Ralston, HJP, Drey EA, Partridge JC, Rosen MA. Fetal pain. JAMA. 2005;294(8):947–54.Google ScholarPubMed
Danzer, E, Adzick, NS, Rintoul, NE, Zarnow, DM, Schwartz, ES, Melchionni, J, et al. Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings. J Neurosurg Pediatr. 2008;2(6):406–13.CrossRefGoogle ScholarPubMed
Moldenhauer, JS, Soni, S, Rintoul, NE, Spinner, SS, Khalek, N, Martinez-Poyer, J, et al. Fetal myelomeningocele repair: the post-MOMS experience at the Children’s Hospital of Philadelphia. Fetal Diagn Ther. 2015;37(3):235–40.CrossRefGoogle ScholarPubMed
Belfort, MA, Whitehead, WE, Shamshirsaz, AA, Ruano, R, Cass, DL, Olutoye, OO. Fetoscopic repair of meningomyelocele. Obstet Gynecol. 2015;126(4):881–4.CrossRefGoogle ScholarPubMed
Verbeek, RJ, Heep, A, Maurits, NM, Cremer, R, Hoving, EW, Brouwer, OF, et al. Fetal endoscopic myelomeningocele closure preserves segmental neurological function. Dev Med Child Neurol. 2012;54(1):1522.CrossRefGoogle ScholarPubMed
Pedreira, DAL, Zanon, N, Nishikuni, K, RAM, De Sá, Acacio, GL, Chmait, RH, et al. Endoscopic surgery for the antenatal treatment of myelomeningocele: the CECAM trial. Am J Obstet Gynecol. 2015;214(1):111.e1.CrossRefGoogle ScholarPubMed
Flake, A. Percutaneous minimal-access fetoscopic surgery for myelomeningocele—not so minimal! Ultrasound Obstet Gynecol. 2014;44(5):499500.CrossRefGoogle Scholar
Cohen, AR, Couto, J, Cummings, JJ, Johnson, A, Joseph, G, Kaufman, BA, et al. Position statement on fetal myelomeningocele repair. Am J Obstet Gynecol. 2014;210(2):107–11.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the or variations. ‘’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats