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Chapter 12 - Relevant pharmacology for neurovascular procedures

Published online by Cambridge University Press:  05 September 2016

Rakesh Khatri
Fort Wayne Neurological Center, Indiana
Gustavo J. Rodriguez
Hennepin Stroke Center, Minneapolis
Jean Raymond
Université de Montréal
Adnan I. Qureshi
University of Minnesota
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Publisher: Cambridge University Press
Print publication year: 2016

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Patanwala, AE, Keim, SM, Erstad, BL. Intravenous opioids for severe acute pain in the emergency department. Ann Pharmacother. 2010;44:1800–09.CrossRefGoogle ScholarPubMed
McDowell, TS, Durieux, ME. Pharmacology of local anesthetics. In: Hemmings, HC, Hopkins, PM, eds. Foundations of anesthesia. 2nd edn. Mosby: Elsevier; 2006. Available at Accessed May 2013.Google Scholar
Weinberg, GL. Lipid emulsion infusion: Resuscitation for local anesthetic and other drug overdose. Anesthesiology. 2012;117:180–7.CrossRefGoogle ScholarPubMed
Hirsch, LJ, Gaspard, N. Status epilepticus. Epilepsy. 2013;19(3):767–94.Google ScholarPubMed
Brophy, GM, Bell, R, Claassen, J, et al. Guidelines for the evaluation and management of status epilepticus. Neuro Crit Care. 2012;17(1):323.Google ScholarPubMed
Huisman, MV, Lip, GY, Diener, HC, et al. Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: resolving uncertainties in routine practice. Thromb Haemost. 2012;107(5):838–47.CrossRefGoogle ScholarPubMed
Marlu, R, Hodaj, E, Paris, A et al. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomized crossover ex vivo study in health volunteers. Thromb Haemost. 2012;108(2):217–24.CrossRefGoogle Scholar
Eerenberg, ES, Kamphuisen, PW, Sijpkens, MK, et al. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011;124(14):1573–9.CrossRefGoogle Scholar
Dager, WE, Gosselin, RC, Roberts, AJ. Reversing dabigatran in life-threatening bleeding occurring during cardiac ablation with factor eight inhibitor bypassing activity. Crit Care Med. 2013;41(5):e42e46.CrossRefGoogle ScholarPubMed
Khoo, TL, Weatherburn, C, Kershaw, G et al. The use of FEIBA® in the correction of coagulation abnormalities induced by dabigatran. Int J Lab Hematol. 2013;35(2):222–4.CrossRefGoogle Scholar
Zhou, W, Schwarting, S, Illanes, S, et al. Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran. Stroke. 2011;42(12):3594–9.CrossRefGoogle Scholar
American College of Chest Physicians. Antithrombotic therapy and prevention of thrombosis, 9th edn: American College of Chest Chysicians evidence-based clinical practice guidelines. Chest. 2012;141(2 Suppl):1S801S.Google Scholar
Makris, M, Van Veen, JJ, Tait, CR, et al. Guideline on the management of bleeding in patients on antithrombotic agents. Br J Haematol. 2013;160(1):3546.CrossRefGoogle ScholarPubMed
Cabral, KP, Fraser, GL, Duprey, J, et al. Prothrombin complex concentrates to reverse warfarin-induced coagulopathy in patients with intracranial bleeding. Clin Neurol Neurosurg. 2013;115(6):770–4.CrossRefGoogle ScholarPubMed
Woo, CH, Patel, N, Conell, C, et al. Rapid warfarin reversal in the setting of intracranial hemorrhage: a comparison of plasma, recombinant activated factor vii, and prothrombin complex concentrate. World Neurosurg. 2014;81(1):110–5.CrossRefGoogle ScholarPubMed
Georgiadis, A, Shah, Q, Suri, MF, Qureshi, AI. Adjunct bivalirudin dosing protocol for neuro-endovascular procedures. J Vasc Interv Neurol. 2008;1(2):5053.Google ScholarPubMed
Hassan, AE, Memon, MZ, Georgiadis, AL, et al. Safety and tolerability of high-intensity anticoagulation with bivalirudin during neuroendovascular procedures. Neurocrit Care. 2011;15(1):96100.CrossRefGoogle Scholar
Fiorella, D. Anti-thrombotic medications for the neurointerventionist: aspirin and clopidogrel. J Neurointerv Surg. 2010;2(1):44–9.CrossRefGoogle Scholar
Akbari, SH, Reynolds, MR, Kadkhodayan, Y, Cross, DT III, Moran, CJ. Hemorrhagic complications after prasugrel (Effient) therapy for vascular neurointerventional procedures. J Neurointerv Surg. 2012;5(4):337–43.Google ScholarPubMed
Dumont, TM, Kan, P, Snyder, KV, et al. Adjunctive use of eptifibatide for complication management during elective neuroendovascular procedures. J Neurointerv Surg. 2013;5(3):226–30.CrossRefGoogle ScholarPubMed
Velat, GJ, Burry, MV, Eskioglu, E, et al. The use of Abciximab in the treatment of acute cerebral thromboembolic events during neuroendovascular procedures. Surg Neurol. 2006;65(4):352–8.CrossRefGoogle Scholar
Walsh, RD, Barrett, KM, Aguilar, MI, et al. Intracranial hemorrhage following neuroendovascular procedures with Abciximab is associated with high mortality: a multicenter series. Neurocrit Care. 2011;15(1):8595.CrossRefGoogle ScholarPubMed
Abdihalim, MM, Hassan, AE, Qureshi, AI. Off-label use of drugs and devices in the neuroendovascular suite. Am J Neuroradiol. 2013;34(11):2054–63.CrossRefGoogle ScholarPubMed
Weant, KA, Ramsey, CN, Cook, AM. Role of intrarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage. Pharmacotherapy. 2010;30(4):405–17.CrossRefGoogle Scholar
Ruiz-Salmeron, RJ, Mora, R, Masotti, M, Betriu, A. Assessment of the efficacy of phentolamine to prevent radial artery spasm during cardiac catheterization procedures: a randomized study comparing phentolamine vs. verapamil. Catheter Cardiovasc Interv. 2005;66(2):192–8.CrossRefGoogle ScholarPubMed
Sehy, JV, Holloway, WE, Lin, SP, et al. Improvement in angiographic cerebral vasospasm after intra-arterial verapamil administration. Am J Neuroradiol. 2013;31:1923–8.Google Scholar
Marraffa, JM, Cohen, V, Howland, MA. Antidotes for toxicological emergencies: A practical review. Am J Hosp Phar. 2012;69(3):199212.Google Scholar
Kerns, W II. Management of β-adrenergic blocker and calcium channel antagonist toxicity. Emerg Med Clin North Am. 2007;25:309–31.CrossRefGoogle ScholarPubMed
Levine, M, Curry, SC, Padilla-Jones, A, Ruha, AM. Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: A 25 year experience at a single center. Ann Emerg Med. 2013;62(3):252–8.CrossRefGoogle Scholar
Holger, JS, Stellpflug, SJ, Cole, JB, Harris, CR, Engebretsen, KM. High-dose insulin: A consecutive case series in toxin-induced cardiogenic shock. Clin Tox. 2011;49:653658.CrossRefGoogle ScholarPubMed
American College of Radiology. Manual on Contrast Media 9th edn. Reston, VA: ACR; 2013.Google ScholarPubMed
Shah, QA, Memon, MZ, Suri, MFK, et al. Super-selective intra-arterial magnesium sulfate in combination with nicardipine for the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage. Neurocrit Care. 2009;11:190–8.CrossRefGoogle ScholarPubMed
Lazaridis, C, Neyens, R, Bodle, J, DeSantis, SM. High-osmolarity saline in neurocritical care: Systematic review and meta-analysis. Crit Care Med. 2013;41(5):1353–40.CrossRefGoogle Scholar
Mancuso, CE, Tanzi, MG, Gabay, M. Paradoxical reactions to benzodiazepines: Literature review and treatment options. Pharmacotherapy 2004;24(9):1177–85.CrossRefGoogle ScholarPubMed
Miner, JR, Danahy, M, Moch, A, Biros, M. Randomized clinical trial of etomidate versus propofol for procedural sedation in the emergency department. Ann Emerg Med 2005;49(1):1522.CrossRefGoogle Scholar
Burton, JH, Miner, JR, Shipley, ER, et al. Propofol for emergency department procedural sedation and analgesia: a tale of three centers. Acad Emerg Med 2006;13(1):2430.CrossRefGoogle ScholarPubMed
Miner, JR, Bachman, A, Kosman, L, et al. Assessment of the onset and persistence of amnesia during procedural sedation with propofol. Acad Emerg Med 2005;12(6):491–6.CrossRefGoogle ScholarPubMed
Miner, JR, Biros, M, Krieg, S, et al. Randomized clinical trial of propofol versus methohexital for procedural sedation during fracture and dislocation reduction in the emergency department. Acad Emerg Med 2003; 10:931–7.CrossRefGoogle Scholar
2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2010; 122(18)(suppl 3):S640S933.CrossRefGoogle ScholarPubMed
ECC Committee, Subcommittee and Task Forces of the American Heart Association. 2005 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2005; 112(24)(suppl):IV1IV203.Google Scholar
Bauer, SR, Lam, SW. Arginine vasopressin for the treatment of septic shock in adults. Pharmacotherapy. 2010;30(10):1057–71.CrossRefGoogle ScholarPubMed

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