Book contents
- Frontmatter
- Contents
- Preface
- Foreword
- List of contributors
- 1 Coated vesicles: a morphologically distinct subclass of endocytic vesicles
- 2 Coated vesicles in different cell types: some functional implications
- 3 Coated vesicles: their occurrence in different plant cell types
- 4 Immunoglobulin transmission in mammalian young and the involvement of coated vesicles
- 5 Coated vesicles in neurons
- 6 Coated vesicles in the oocyte
- 7 Adsorptive and passive pinocytic uptake
- 8 Coated vesicles and receptor biology
- 9 Coated secretory vesicles
- 10 Dynamic aspects of coated vesicle function
- 11 Structural aspects of coated vesicles at the molecular level
- 12 Coated vesicles in medical science
- Appendix 1 Nomenclature
- Appendix 2 References added at proof
- Author index
- Subject index
- Plate section
8 - Coated vesicles and receptor biology
Published online by Cambridge University Press: 04 August 2010
- Frontmatter
- Contents
- Preface
- Foreword
- List of contributors
- 1 Coated vesicles: a morphologically distinct subclass of endocytic vesicles
- 2 Coated vesicles in different cell types: some functional implications
- 3 Coated vesicles: their occurrence in different plant cell types
- 4 Immunoglobulin transmission in mammalian young and the involvement of coated vesicles
- 5 Coated vesicles in neurons
- 6 Coated vesicles in the oocyte
- 7 Adsorptive and passive pinocytic uptake
- 8 Coated vesicles and receptor biology
- 9 Coated secretory vesicles
- 10 Dynamic aspects of coated vesicle function
- 11 Structural aspects of coated vesicles at the molecular level
- 12 Coated vesicles in medical science
- Appendix 1 Nomenclature
- Appendix 2 References added at proof
- Author index
- Subject index
- Plate section
Summary
It is a usual assumption that the selective transport of proteins across cell plasma membranes is mediated by receptor molecules located in the membranes. The function of such receptors is to bind those molecules for which they have the correct stereospecificity. The binding process is usually saturable and occurs with a high affinity between receptor and protein. When the receptor–protein complex is subsequently internalised by endocytosis it may be either utilised in some metabolic function or translocated to a site suitable for exocytosis at the basolateral membrane. From there it may be absorbed by the vascular system.
We shall discuss in this chapter the various models which elaborate these basic concepts, with particular emphasis on the role and fate of the receptor molecule. Evidence for and against the involvement of receptors will be presented and an evaluation of the transport models will be attempted in the light of such evidence. Finally we shall propose some experimental approaches which might resolve some of the more ill-understood areas of the subject.
General properties of receptors
The concept of a ‘receptor’ was introduced about 100 years ago by Langley (1878). Langley's work on the response of certain muscle cells to nicotine led to the idea of a ‘receptive substance’ at the site of application of the drug. Later work by Ehrlich allowed a generalisation of the concept and the receptor became identified with the role of a recognition site for a specific region of a drug or ligand.
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- Information
- Coated Vesicles , pp. 219 - 242Publisher: Cambridge University PressPrint publication year: 1980
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