Published online by Cambridge University Press: 19 October 2021
Psychiatry is the youngest medical specialty, with continually evolving methods of disease classification, models of pathogenesis, and concepts about evidence-based management. One of the greatest advances in the treatment of schizophrenia comes from sophisticated analyses of clinical trials data, with a view to identifying patients who appear unlikely to respond to the current treatment condition (i.e. the current dose of the psychotropic) regardless of how much time they are given . These analyses are not a trivial exercise, but a concerted effort to minimize unnecessary patient suffering when clinicians delay changes in dose (or medication), waiting for delayed response.