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15 - Olanzapine and Olanzapine Pamoate

Published online by Cambridge University Press:  19 October 2021

Jonathan M. Meyer
University of California, San Diego
Stephen M. Stahl
University of California, Riverside and San Diego
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Olanzapine is among the more extensively studied second-generation antipsychotics (SGAs), partly due to its approval 25 years ago (1996), and also due to its penchant for significant metabolic adverse effects [9, 10]. Olanzapine distinguished itself by its efficacy profile (Figure 15.1), combined with lower rates of hyperprolactinemia and neurological adverse effects than first-generation antipsychotics (FGAs) and risperidone [11]. In the US Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia study, the primary outcome measure was time to all-cause discontinuation, and olanzapine outperformed other antipsychotics in phase 1 [12].

The Clinical Use of Antipsychotic Plasma Levels
Stahl's Handbooks
, pp. 296 - 317
Publisher: Cambridge University Press
Print publication year: 2021

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