Skip to main content Accessibility help
Hostname: page-component-768dbb666b-x9ds4 Total loading time: 1.061 Render date: 2023-02-05T11:51:27.957Z Has data issue: true Feature Flags: { "useRatesEcommerce": false } hasContentIssue true

Chapter 10 - Deep hypothermic circulatory arrest

Published online by Cambridge University Press:  05 December 2015

Sunit Ghosh
Papworth Hospital, Cambridge
Florian Falter
Papworth Hospital, Cambridge
Albert C. Perrino, Jr
Yale University, Connecticut
Get access
Cardiopulmonary Bypass , pp. 152 - 167
Publisher: Cambridge University Press
Print publication year: 2015

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)


Suggested Further Reading

Al-Hashimi, S, Zaman, M, Waterworth, P, Bilal, H. Does the use of thiopental provide added cerebral protection during deep hypothermic circulatory arrest? Interact Cardiovasc Thorac Surg 2013; 17(2): 392–7.
Arrowsmith, JE, Ganugapenta, MSSR. Intraoperative brain monitoring in cardiac surgery. In: Bonser, R, Pagano, D, Haverich, A (Eds). Brain Protection in Cardiac Surgery. London: Springer-Verlag. 2011.;pp 83111.
Bigelow, WG, Lindsay, WK, Greenwood, WF. Hypothermia; its possible role in cardiac surgery: an investigation of factors governing survival in dogs at low body temperatures. Ann Surg 1950; 132(5): 549–66.
Chau, KH, Friedman, T, Tranquilli, M, Elefteriades, JA. Deep hypothermic circulatory arrest effectively preserves neurocognitive function. Ann Thorac Surg 2013; 96(5): 1553–9.
Coselli, JS, Lemaire, SA, Koksoy, C, Schmittling, ZC, Curling, PE. Cerebrospinal fluid drainage reduces paraplegia after thoracoabdominal aortic aneurysm repair: results of a randomized clinical trial. J Vasc Surg 2002; 35(4): 631–9.
Dorotta, I, Kimball-Jones, P, Applegate, R, 2nd. Deep hypothermia and circulatory arrest in adults. Semin Cardiothorac Vasc Anesth 2007; 11(1): 6676.
Duebener, LF, Sakamoto, T, Hatsuoka, S, et al. Effects of hematocrit on cerebral microcirculation and tissue oxygenation during deep hypothermic bypass. Circulation 2001; 104(12 Suppl 1): I260–4.
Ergin, MA, Galla, JD, Lansman, L, et al. Hypothermic circulatory arrest in operations on the thoracic aorta. Determinants of operative mortality and neurologic outcome. J Thorac Cardiovasc Surg 1994; 107(3): 788–97.
Harrington, DK, Lilley, JP, Rooney, SJ, Bonser, RS. Nonneurologic morbidity and profound hypothermia in aortic surgery. Ann Thorac Surg 2004; 78(2): 596601.
Hoffman, GM. Neurologic monitoring on cardiopulmonary bypass: what are we obligated to do? Ann Thorac Surg 2006; 81(6): S2373-80.
Hogue, CW Jr., Palin, CA, Arrowsmith, JE. Cardiopulmonary bypass management and neurologic outcomes: an evidence-based appraisal of current practices. Anesth Analg 2006; 103(1): 2137.
Jonas, RA, Bellinger, DC, Rappaport, LA, et al. Relation of pH strategy and developmental outcome after hypothermic circulatory arrest. J Thorac Cardiovasc Surg 1993; 106(2): 362–8.
Khaladj, N, Shrestha, M, Meck, S, et al. Hypothermic circulatory arrest with selective antegrade cerebral perfusion in ascending aortic and aortic arch surgery: a risk factor analysis for adverse outcome in 501 patients. J Thorac Cardiovasc Surg 2008; 135(4): 908–14.
Milewski, RK, Pacini, D, Moser, GW, et al. Retrograde and antegrade cerebral perfusion: results in short elective arch reconstructive times. Ann Thorac Surg 2010; 89(5): 1448–57.
Ono, M, Brown, C, Lee, JK, et al. Cerebral blood flow autoregulation is preserved after hypothermic circulatory arrest. Ann Thorac Surg 2013; 96(6): 2045–53.
Priestley, MA, Golden, JA, O’Hara, IB, McCann, J, Kurth, CD. Comparison of neurologic outcome after deep hypothermic circulatory arrest with alpha-stat and pH-stat cardiopulmonary bypass in newborn pigs. J Thorac Cardiovasc Surg 2001; 121(2): 336–43.
Shum-Tim, D, Tchervenkov, CI, Jamal, AM, et al. Systemic steroid pretreatment improves cerebral protection after circulatory arrest. Ann Thorac Surg 2001; 72(5): 1465–71.
Svensson, LG, Crawford, ES, Hess, KR, et al. Deep hypothermia with circulatory arrest. Determinants of stroke and early mortality in 656 patients. J Thorac Cardiovasc Surg 1993; 106(1): 1928.
Treasure, T. The safe duration of total circulatory arrest with profound hypothermia. Ann R Coll Surg Engl 1984; 66(4): 235–40.
Vuylsteke, A, Sharples, L, Charman, G, et al. Circulatory arrest versus cerebral perfusion during pulmonary endarterectomy surgery (PEACOG): a randomised controlled trial. Lancet 2011; 378(9800): 1379–87.

Save book to Kindle

To save this book to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the or variations. ‘’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats