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17 - Brain systems underlying anxiety disorders: a view from neuroimaging

from Section 3 - Understanding the causes of anxiety

Published online by Cambridge University Press:  10 November 2010

Helen Blair Simpson
Affiliation:
Columbia University, New York
Yuval Neria
Affiliation:
Columbia University, New York
Roberto Lewis-Fernández
Affiliation:
Columbia University, New York
Franklin Schneier
Affiliation:
Columbia University, New York
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Summary

This chapter explores that clinical anxiety involves changes in brain systems that are involved in the generation and regulation of normal emotion. It focuses on a core circuit for negative affective reactivity identified in animal and human studies of fear conditioning. The executive working memory system is a set of cortical networks that comprise a system for goal-directed, flexible control over attention and memory. The affective appraisal system is a set of paralimbic cortical and subcortical regions involved in emotion generation and regulation, self-related cognition, long-term memory retrieval, and context based modulation of conditioned fear. The number of functional neuroimaging studies of negative emotion in clinical anxiety disorders has grown at a rapid pace, now reaching a point at which a quantitative meta-analytic review is feasible. Compared to depression, relatively few neuroimaging coupled intervention studies have been reported for each anxiety disorder.
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Anxiety Disorders
Theory, Research and Clinical Perspectives
, pp. 192 - 203
Publisher: Cambridge University Press
Print publication year: 2010

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