Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-18T08:55:37.219Z Has data issue: false hasContentIssue false

Chapter 15 - Malaria

from Section 3, Part D - Hemolytic Anemias

Published online by Cambridge University Press:  18 April 2018

By
Michael A. McDevitt  and
Richard Bucala
Edited by
Edward J. Benz, Jr. ,
Nancy Berliner  and
Fred J. Schiffman
Edward J. Benz, Jr.
Affiliation:
Dana Farber Cancer Institute
Nancy Berliner
Affiliation:
Brigham and Women's Hospital, Boston
Fred J. Schiffman
Affiliation:
Children's Hospital, Boston
Get access

Summary

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Anemia
Pathophysiology, Diagnosis, and Management
 , pp. 108 - 112
Publisher: Cambridge University Press
Print publication year: 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Murray, CJ, Rosenfeld, LC, Lim, SS, Andrews, KG, Foreman, KJ, Haring, D, Fullman, N, Naghavi, M, Lozano, R, Lopez, AD. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet. 2012; 379:413–431.Google Scholar
McDevitt, M, Xie, J, Gordeuk, V, Bucala, R. The anemia of malaria infection: role of inflammatory cytokines. Curr Hematol Rep. 2004; 3:97–106.Google ScholarPubMed
Haldar, K, Mohandas, N. Malaria, erythrocytic infection, and anemia. Hematology Am Soc Hematol Educ Program. 2009:87–93.CrossRefGoogle Scholar
Jakeman, PH, Saul, A, Hogarth, WL, Collins, WE. Anaemia of acute malaria infections in non-immune patients primarily results from destruction of uninfected erythrocytes. Parasitology. 2004; 119:127–133.CrossRefGoogle Scholar
Waitumbi, J, Opollo, M, Muga, R, Misore, A, Stoute, J. Red cell surface changes and erythrophagocytosis in children with severe Plasmodium falciparum anemia. Blood. 2000;95:1481–1486.CrossRefGoogle ScholarPubMed
Stoute, JA, Odindo, AO, Owuor, BO, Mibei, EK, Opollo, MO, Waitumbi, JN. Loss of red blood cell-complement regulatory proteins and increased levels of circulating immune complexes are associated with severe malarial anemia. J Infect Dis. 2003; 187:522–525.CrossRefGoogle ScholarPubMed
Weatherall, D, Kwiatkowski, D, Roberts, D. Hematologic manifestations of systemic disease in children of the developing world. In: Orkin, SH, Ginsburg, D, Nathan, DG, Look, TA, Fisher, DE, Lux, SE, editors, Nathan and Oski?s Hematology and Oncology of Infancy and Childhood, 8th edition, Amsterdam: Elsevier; 2008.Google Scholar
Wickramasinghe, S, Abdalla, S. Blood and bone marrow changes in malaria. Baillieres Best Pract Res Clin Haematol. 2003; 13:277–299.Google Scholar
Abdalla, SH. Hematopoiesis in human malaria. Blood Cells. 1990; 16:401–416.Google ScholarPubMed
Srichaikul, T, Wasanasomsithi, M, Poshyachinda, V, Panikbutr, N, Rabieb, T. Ferrokinetic studies and erythropoiesis in malaria. Arch Intern Med. 1969; 124:623–628.Google Scholar
Biemba, G, Gordeuk, V, Thuma, P, Mabeza, GF, Weiss, G. Prolonged macrophage activation and persistent anemia in children with complicated malaria. Trop Med Int Health. 1998; 3:60–65.Google Scholar
Das, B, Nanda, N, Rath, P, Satapathy, R, Das, D. Anaemia in acute Plasmodium falciparum malaria in children from the Orissa state, India. Ann Trop Med Parasitol. 1999; 93:109–118.Google Scholar
Lamikanra, AA, Theron, M, Kooij, TW, Roberts, DJ. Hemozoin (malarial pigment) directly promotes apoptosis of erythroid precursors. PLoS One. 2009;4:e8446.CrossRefGoogle ScholarPubMed
Kremsner, PG, Valim, C, Missinou, MA, Olola, C, Krishna, S, Issifou, S, Kombila, M, Bwanaisa, L, Mithwani, S, Newton, CR, Agbenyega, T, Pnder, M, Bojang, K, Wypij, D, Taylor, T. Prognostic value of circulating pigmented cells in African children with malaria. J Infect Dis. 2009; 199:142–150.CrossRefGoogle ScholarPubMed
Stevenson, MM, Riley, EM. Innate Immunity to Malaria. Nat Revs Immunol. 2004; 4:169–180.CrossRefGoogle ScholarPubMed
Yap, GS, Stevenson, MM. Inhibition of in vitro erythropoiesis by soluble mediators during Plasmodium chabaudi AS malaria: lack of a major role for interleukin-1, tumor necrosis factor-α, and γ-interferon. Infect Immun. 1994; 62:357–362.CrossRefGoogle Scholar
Kwiatkowski, D, Cannon, JG, Manogue, KR, Cerami, A, Dinarello, CA, Greenwood, BM. Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture. Clin Exp Immunol. 1989; 77:361–366.Google Scholar
Thuma, PE, van Dijk, J, Bucala, R, Debebe, Z, Nekhai, S, Kuddo, T, Nouraie, M, Weiss, G, Gordeuk, VR. Distinct clinical and immunologic profiles in severe malarial anemia and cerebral malaria in Zambia. J Infect Dis. 2011; 203:211–219.Google Scholar
Looareesuwan, S, Merry, AH, Phillips, RE, Pleehachinda, R, Wattanagoon, Y, Ho, M, Charoenlarp, P, Warrell, DA, Weatherall, DJ. Reduced erythrocyte survival following clearance of malarial parasitaemia in Thai patients. Br J Haematol. 1987; 67:473–478.CrossRefGoogle ScholarPubMed
Nicolas, G, Chauvet, C, Viatte, L, Danan, JL, Bigard, X, Devaux, I, Beaumont, C, Kahn, A, Vaulont, S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002; 110:1037–1044.CrossRefGoogle ScholarPubMed
Burté, F, Brown, BJ, Orimadegun, AE, Ajetunmobi, WA, Afolabi, NK, Akinkunmi, F, Kowobari, O, Omokhodion, S, Osinusi, K, Akinbami, FO, Shokunbi, WA, Sodeinde, O, Fernandez-Reyes, D. Circulatory hepcidin is associated with the anti-inflammatory response but not with iron or anemic status in childhood malaria. Blood. 2013; 121:3016–3022.Google Scholar
Burchard, G, Radloff, P, Philipps, J, Nkeyi, M, Knobloch, J, Kremsner, P. Increased erythropoietin production in children with severe malarial anemia. Am J Trop Med Hyg. 1995; 53:547–551.CrossRefGoogle ScholarPubMed
Burgmann, H, Looareesuwan, S, Kapiotis, S, Viravan, C, Vanijanonta, S, Hollenstein, U, Wiesinger, E, Presterl, E, Winkler, S, Graninger, W. Serum levels of erythropoietin in acute Plasmodium falciparum malaria. Am J Trop Med Hyg. 1996; 54:280–283.Google Scholar
Griffith, JW, Sun, T, McIntosh, MT, Bucala, R. Pure hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J Immunol. 2009; 183:5208–5220.CrossRefGoogle ScholarPubMed
Dodoo, D, Omer, FM, Todd, J, Akanmori, BD, Koram, KA, Riley, EM. Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria. J Infect Dis. 2002; 185:971–979.CrossRefGoogle ScholarPubMed
Mohan, K, Stevenson, MM. Interleukin-12 corrects severe anemia during blood-stage Plasmodium chabaudi AS in susceptible A/J mice. Exp Hematol. 1998; 26:45–52.Google ScholarPubMed
Mcguire, W, Knight, JC, Hill, AVS, Allsopp, CEM, Greenwood, BM, Kwiatkowski, D. Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. J Infect Dis. 1999; 179:287–290.Google Scholar
McDevitt, MA, Xie, J, Shanmugasundaram, G, Griffith, J, Liu, A, McDonald, C, Thuma, P, Gordeuk, VR, Metz, CN, Mitchell, R, Keefer, J, David, J, Leng, L, Bucala, R. A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med. 2006; 203:1185–1196.Google Scholar
Zhong, XB, Leng, L, Beitin, A, Chen, R, McDonald, C, Hsiao, B, Jenison, RD, Kang, I, Park, SH, Lee, A, Gregersen, P, Thuma, P, Bray-Ward, P, Ward, DC, Bucala, R. Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies. Nucleic Acids Res. 2005;33:121–129.Google Scholar
Awandare, GA, Martinson, JJ, Were, T, Ouma, C, Davenport, GC, Ong’echa, JM, Wang, WK, Leng, L, Ferrell, RE, Bucala, R, Perkins, DJ. MIF promoter polymorphisms and susceptibility to severe malarial anemia. J Infect Dis. 2009; 15:629–637.Google Scholar
Jha, AN, Sundaradival, P, Pati, SS, Patra, PK, Thandaraj, K. Variations in ncRNA gene LOC284889 and MIF-794CATT repeats are associated with malaria susceptibility in Indian populations. Malar J. 2013;12:345–353.Google Scholar
Published Reports of Delayed Hemolytic Anemia After Treatment with Artesunate for Severe Malaria – Worldwide, 2010–2012. Morb Mortal Wkly Rep. 2013;62(1):5–8.Google Scholar
Akinosoglou, KS, Solomou, EE, Gogos, CA. Malaria: a haematological disease. Hematology. 2012; 17:106–114.Google Scholar
English, M, Ahmed, M, Ngando, C, Berkley, J, Ross, A. Blood transfusion for severe anaemia in children in a Kenyan hospital. Lancet. 2002; 359:494–495.Google Scholar
van Genderen, PJ, Hesselink, DA, Bezemer, JM, Wismans, PJ, Overbosch, D. efficacy and safety of exchange transfusion as adjunct therapy for severe Plasmodium falciparum malaria in nonimmune travelers: a 10 year single-center experience with a standardized treatments protocol. Transfusion. 2010; 50:787–794.CrossRefGoogle Scholar
Nieuwenhuis, JA, Meertens, JH, Zijlstra, JG, Ligtenberg, JJ, Tulleken, JE, van der Werf, TS. Automated erythrocytapheresis in severe falciparum malaria: a critical appraisal. Acta Trop. 2006; 98:201–206.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×