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9A - There Is a Role for Pre-conceptional Treatment with Vitamin D

For

from Section II - IVF Add-ons

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

Vitamin D deficiency is common, and its correction has been suggested as a simple and safe way of improving IVF treatment outcomes. Vitamin D has been found to be of importance in implantation and the development of normal pregnancy. Deficiency has been associated with complications such as fetal growth restriction and pre-eclampsia. It has been suggested that routine testing and correction of vitamin D deficiency should be carried out on all women undergoing IVF treatment. Despite published evidence suggesting that this strategy should be employed, testing and treatment of vitamin D deficiency is still not routine practice in infertile women. Treating vitamin D deficiency should be undertaken in women seeking fertility treatment to optimise the chances of success and to reduce the risks of obstetric complications.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2021

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References

Lerchbaum, E, Obermayer-Pioetsch, B. Mechanisms in endocrinology: Vitamin D and fertility: a systematic review. Eur J Endocrinol. 2012;166(5):765–78.CrossRefGoogle Scholar
Holick, M, Binkley, NC, Bischoff-Ferrari, HA, et al. Full guideline: evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.CrossRefGoogle Scholar
Chu, J, Gallos, I, Tobias, A, Tan, B, Eapen, A, Coomarasamy, A. Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis, Hum Reprod. 2018;33(1):6580.CrossRefGoogle ScholarPubMed
Chu, J, Gallos, I, Tobias, A, et al. Vitamin D and assisted reproductive treatment outcome: a prospective cohort study. Reprod Health. 2019;16(1):106.CrossRefGoogle ScholarPubMed
NICE. Vitamin D: supplement use in specific population groups. NICE Public Health Guideline. 2014; www.nice.org.uk/guidance/ph56.Google Scholar

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